The recommended dosage of AYVAKIT for patients with indolent systemic mastocytosis (ISM) is 25 mg orally, daily1

Medication pill

One 25-mg tablet orally

Do not eat or drink at least one hour before or at least two hours after taking AYVAKIT

On an empty stomach, at least 1 hour before or at least 2 hours after a meal

Clock

Once a day

A modified starting dosage of AYVAKIT is recommended for patients with severe hepatic impairment (Child-Pugh Class C): 25 mg orally every other day.1

Avoid concomitant use of AYVAKIT with strong or moderate CYP3A inhibitors or inducers. If contraception requires estrogen, limit ethinyl estradiol to ≤20 mcg unless a higher dose is necessary.1

Clear from the start: It is important to set the right expectations with patients who are beginning AYVAKIT treatment and check in along the way

Works differently

AYVAKIT works by inhibiting KIT D816V, the gene mutation responsible for the overproduction of abnormal hyperactive mast cells—the source of ISM symptoms.1-4

Taken Consistently

AYVAKIT is usually taken 1 time each day, not on an as-needed basis1

Experienced over time

AYVAKIT may take time to start working. In the clinical trial, patients saw a significant reduction in symptom burden at 6 months on treatment1

See the stories of real patients living with ISM taking AYVAKIT

PATIENT STORIES

Real patient. Image of spouse used with consent.

Real patient family photos

References: 1. AYVAKIT [prescribing information]. Cambridge, MA: Blueprint Medicines Corporation; November 2024. 2. Kristensen T et al. Am J Hematol. 2014;89 (5):493-498. 3. Garcia-Montero AC et al. Blood. 2006;108(7):2366-2372. 4. Ungerstedt J et al. Cancers. 2022;14(16):3942.