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Indolent ISMAdvanced SMPDGFRA GIST
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  About ISM  
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Indolent ISMAdvanced SMPDGFRA GIST
AYVAKIT® (avapritinib) 25 mg white logo

Patients with ISM can experience a high symptom burden that may impact work and daily life5,6

Symptoms (including skin, neurocognitive, and GI) can be heterogeneous, chronic, and potentially debilitating5-7

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Symptoms Statistics Graphic65% Statistics Graphic80% Statistics Graphic76% Statistics Graphic
65%
of patients reported experiencing nervous system disorders*
80%
of patients reported experiencing GI disorders*
76%
of patients reported experiencing skin and subcutaneous tissue disorders*

*Data based on ongoing medical history events in the PIONEER study (N=212). Events ≥10% in 1 or both trial arms from 3 of the organ classes include pruritus, urticaria pigmentosa, urticaria, rash maculo-papular for skin and subcutaneous tissue disorders; headache, dizziness, migraine, memory impairment, disturbance in attention for nervous system disorders; and diarrhea, abdominal pain, nausea, gastroesophageal reflux disease, abdominal distension, constipation for GI disorders.6

Patients may also take multiple symptom-directed therapies and visit HCPs frequently due to their ISM6†
symptom burden graphic
In the same patient survey, of the patients with moderate to severe ISM (n=32), 72% reported visiting HCPs ≥7 times in 1 year6†
HCP Visits in 1 Year, as Reported by Patients With Moderate to Severe ISM (n=32)6†
HCP visits chart graphic

†In the Blueprint Medicines–sponsored TouchStone SM Patient Survey, US adults with a self-reported SM diagnosis (N=56) completed an online survey of 100 items. An analysis was conducted in patients with ISM (n=37), including 32 patients with moderate to severe ISM (defined as an ISM-SAF TSS ≥28) and results were analyzed using descriptive statistics. These analyses were made from the TouchStone SM Patient Survey but have not been published.6

Historically, there have been no approved therapies for ISM5
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Learn about the first and only approved treatment option for ISM1
About Ayvakit
GI=gastrointestinal; HCP=healthcare provider; OTC=over the counter; SM=systemic mastocytosis.
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INDICATION

AYVAKIT® (avapritinib) is indicated for the treatment of adult patients with indolent systemic mastocytosis (ISM).

Limitations of Use: AYVAKIT is not recommended for the treatment of patients with ISM with platelet counts of <50 x 109/L.

IMPORTANT SAFETY INFORMATION
INDICATION & IMPORTANT SAFETY INFORMATION

Intracranial Hemorrhage (ICH)—Serious ICH may occur with AYVAKIT treatment; fatal events occurred in <1% of patients. No events of ICH occurred in the 246 patients with ISM who received any dose of AYVAKIT in the PIONEER study.

Monitor patients closely for risk factors of ICH which may include history of vascular aneurysm, ICH or cerebrovascular accident within the prior year, concomitant use of anticoagulant drugs, or thrombocytopenia.

Symptoms of ICH may include headache, nausea, vomiting, vision changes, or altered mental status. Advise patients to seek immediate medical attention for signs or symptoms of ICH.

Permanently discontinue AYVAKIT if ICH of any grade occurs.

Cognitive Effects—Cognitive adverse reactions can occur in patients receiving AYVAKIT and occurred in 7.8% of patients with ISM who received AYVAKIT + best supportive care (BSC) versus 7.0% of patients who received placebo + BSC; <1% were Grade 3. Depending on the severity, withhold AYVAKIT and then resume at the same dose, or permanently discontinue AYVAKIT.

Photosensitivity—AYVAKIT may cause photosensitivity reactions. In all patients treated with AYVAKIT in clinical trials (n=1049), photosensitivity reactions occurred in 2.5% of patients. Advise patients to limit direct ultraviolet exposure during treatment with AYVAKIT and for one week after discontinuation of treatment.

Embryo-Fetal Toxicity—AYVAKIT can cause fetal harm when administered to a pregnant woman. Advise pregnant women of the potential risk to a fetus. Advise females and males of reproductive potential to use an effective contraception during treatment with AYVAKIT and for 6 weeks after the final dose. Advise women not to breastfeed during treatment with AYVAKIT and for 2 weeks following the final dose.

Adverse Reactions—The most common adverse reactions (≥10%) in patients with ISM were eye edema, dizziness, peripheral edema, and flushing.

Drug Interactions—Avoid coadministration of AYVAKIT with strong or moderate CYP3A inhibitors or inducers.

To report suspected adverse reactions, contact Blueprint Medicines Corporation at 1-888-258-7768 or the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

Please click here to see the full Prescribing Information for AYVAKIT.

References:

  1. AYVAKIT [prescribing information]. Cambridge, MA: Blueprint Medicines Corporation; May 2023.
  2. Kristensen T et al. Am J Hematol. 2014;89(5):493-498.
  3. Garcia-Montero AC et al. Blood. 2006;108(7):2366-2372.
  4. Ungerstedt J et al. Cancers. 2022;14(16):3942.
  5. Pardanani A. Am J Hematol. 2023;98(7):1097-1116.
  6. Data on file. Blueprint Medicines Corporation, Cambridge, MA. 2023.
  7. Gülen T et al. J Intern Med. 2016;279(3):211-228.
  8. Theoharides TC et al. N Engl J Med. 2015;373(2):163-172.
  9. Gotlib J et al. NEJM Evidence. 2023;2(6). Published online May 23, 2023. doi:10.1056/EVIDoa2200339
  10. Padilla B et al. Orphanet J Rare Dis. 2021;16(1):434.